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OCR: tract is The endocrinology of the gastrointestin he first complex and incompletely understood. from the hormone described, secretin, was isolate ances in gastrointestinal tract in 1902. Further ad were gastrointestinal endocrinology, however niques for limited until recently, when reliable tech low isolating regulatory peptides at extremel concentrations became available. are A variety of gastrointestinal pathologies circulating associated with significant alterations in ought thatconcentrations of gut peptides and it is th le in the under these circumstances, they play a r ponse to adaptation of the gut: for example, in res altering loss of absorptive or secretory surface by ans. secretion and motility in unaffected regi